PRENATAL OPIOID EXPOSURE SIGNIFICANTLY IMPACTS PLACENTAL PROTEIN KINASE C (PKC) AND DRUG TRANSPORTERS, LEADING TO DRUG RESISTANCE AND NEONATAL OPIOID WITHDRAWAL SYNDROME

BackgroundNeonatal Opioid Withdrawal Syndrome (NOWS) is a consequence of in-utero exposure to prenatal maternal opioids, resulting in the manifestation of symptoms like irritability, feeding problems, tremors, and withdrawal signs.Opioid use disorder (OUD) during pregnancy can profoundly impact both mother and fetus, disrupting fetal brain neurotra

Fadi Kayali, Muhamad A Janjua, Damian A Laber, Donald Miller, Goetz H KloeckerUniversity of Louisville, James Graham Brown Cancer Center, Louisville, KY, USABackground: In vitro digoxin sensitizes cancer cells to the induction of apoptosis by chemotherapy.Inhibition of the Na/K-ATPase enzyme by ouabain disturbs the intracellular ion composition of

The purpose of this study was to detect nutrient uptake and assimilation in woody plants subjected to growing media with some peat replaced by spent mushroom residue (SMR).Fragrant rosewood (Dalbergia odorifera T.C.Chen) seedlings were cultured in five types of growing media with SMR and peat in volumetric proportions of 0% (control), 25%, 50%, 75%

Abstract With the deepening of human research on deep space exploration, our research on the soft landing methods of landers has gradually deepened.Adding a buffer and energy-absorbing structure to the leg structure of the lander has become an effective design solution.Based on the energy-absorbing structure of the leg of the interstellar lander, t

Microorganisms with antimicrobial activity have been used to successfully control various plant pathogens.The discovery of organisms with protective activity depends on empirical screenings to assess microbial activity against pathogens of interest.Machine learning can accelerate the discovery process by Fruit Formulas making screening and, thus, d